I am kind of presently playing with it!
I've had a bass guitar and acoustic guitar since highschool, and I just recently bought an electric guitar and a multi-effects processor. I've been pretty interested lately in doing some stuff like
Metroid Metal or
Goat's stuff (I have my own list of songs I'd like to metal-ize) so I figured at the least I could use renoise for drums. Although I still need to find a good multi-track wave editor. Audition seems to be primarily a single-track editor, unless I'm an idiot, which is possible, because at the moment I'm not completely sober.